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KMID : 0878220120240040084
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Journal of Sasang Constitutional Medicine
2012 Volume.24 No. 4 p.84 ~ p.91
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Effects of Yuldahanso-tang and Chungsimyonja-tang on Cytochrome P450 Activities
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Jin Seong-Eun
Ha Hye-Kyung
Shin Hyeun-Kyoo
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Abstract
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Objectives: The purpose of this study is to investigate the inhibitory or inductive potentials of Yuldahanso-tang (YDT) and Chungsimyonja-tang (CST), herbal formulas for Taeeumin, on cytochrome P450 (CYP450) drug metabolizing enzyme. The mechanisms for the herbal formula-drug interaction has not been well reported in spite of the chance for co-administration with conventional drugs.
Methods: To evaluate the interaction potential of YDT-drug or CST-drug, the fluorescence-based enzyme assays on CYP450 isozymes including CYP3A4, CYP2C19, CYP2D6 and CYP2E1 were established in vitro. The inhibitory effects of herbal formulas were characterized with IC50 values.
Results: YDT showed inhibitory effects on CYP2D6 and CYP2E1-mediated metabolism, while it exhibited week inhibition on CYP3A4 and CYP2C19 relatively. CST exerted relatively weak inhibitory effects on the four CYP450 isozymes compared to that of YDT.
Conclusions: These results suggest that the herbal formula-drug interaction could be occur when YDT are co-administered with drugs mediated by CYP2D6 or CYP2E1.
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KEYWORD
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Cytochrome P450, herb-drug interactions, Yuldahanso-tang, Chungsimyonja-tang, Taeeumin
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